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The Study of Osteoporotic Fractures (SOF)

a multicenter, observational study of 10,000 older women.

SOF, a nationwide research study funded by the National Institutes of Health, began in 1986. The study was originally focused on risk factors for fractures and falls and has grown to look at various determinants of successful aging.

SOF Online provides access to the SOF data and documentation.

Data News
1-2-3 Data. Three quick steps to download the clinical data.

What's available as of 07/07/2011
Clinical
(download data from SOF Online)
  • Baseline questionnaire and exam data for original (Caucasian) cohort (N=9,704)
  • Visit 2 (Year 2) questionnaire and exam data for original (Caucasian) cohort
  • Visit 3 (Year 4) questionnaire and exam data for original (Caucasian) cohort
  • Visit 4 (Year 6) questionnaire and exam data for original (Caucasian) cohort
  • Visit 5 (Year 8) questionnaire and exam data for original (Caucasian) cohort
  • Visit 6 (Year 10) questionnaire and exam data for original (Caucasian) cohort and Baseline questionnaire and exam data for African American cohort (N=662)
  • Visit 7 (Year 12) questionnaire and exam data for AA cohort (Visit 2) and subset of Caucasian cohort
  • Visit 8 (Year 16) questionnaire and exam data for entire cohort
  • Visit 9 (Year 20) questionnaire and exam data for entire cohort (additional sleep measures in subset)
  • Outcomes: fractures, breast cancer and mortality
  • Lab Data: Data from multiple assays available in following substudies: Fracture Death Case Cohort, Breast Cancer Case Cohort, and Stroke Case Cohort (See "Data Availability for Public Data Release" in "Data & Documentation" for details)
Biospecimens
Refer to Ancillary Study Guidelines on SOF Online for biospecimen requests
  • Baseline serum for original cohort
  • Visit 2 (Year 2) serum, blood blotters and DNA for original cohort and urine in a subset
  • Visit 4 (Year 6) serum and urine on original cohort
  • Visit 6 (Year 10) serum and urine on entire cohort
  • Visit 7 (Year 12) serum and blood blotters in AA cohort
  • Visit 8 (Year 16) blood blotters, whole blood and DNA on entire cohort

Technical Requirements
SOF Online is designed to work best with Internet Explorer 8+ or FireFox 4+, and Adobe Acrobat 10+. All are freely available.
Site Use
SOF Online is intended as a means to learn about and retrieve the data collected in the Study of Osteoporotic Fractures. By using SOF Online, users imply understanding of these intended uses and agree not to use the website or downloadable materials for any other purpose.
Create an account now!
You must have an account and accept the terms of a Data Use Agreement before you can download or explore clinical data. Please go to My Account and create a new account now.
New Features in Data & Documentation
Tutorial: Where do I begin? Try the SOF Online Tutorial which walks you through the variety of tools available on SOF Online for touring and understanding the data.
Search/browse: Search/browse a database of categorized variable documentation displayed longitudinally with links to statistics, comments, and annotated data collection forms.
My Cart: Create a personal cart of variables of interest that can be used 1) to build a custom codebook able to be read offline, and 2) to filter downloadable datasets.
DataExplorer: Use DataExplorer to generate descriptive statistics: cross tabs, subsets, frequency distributions and more. Note this tool requires an account and acceptance of the terms of a Data Use Agreement.
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